Pink1 - PTEN induced putative kinase 1

Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of dopamine secretion; positive regulation of dopaminergic synaptic transmission; and positive regulation of histone deacetylase activity. Located in endoplasmic reticulum and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Parkinson's disease 6. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Apr 2022]