Chmp2b - charged multivesicular body protein 2B

Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and regulation of synapse organization. Predicted to be located in cytosol. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Predicted to colocalize with late endosome; lysosome; and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; spleen; and vibrissa. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; chromosome 3-linked frontotemporal dementia; and frontotemporal dementia. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Apr 2022]