Nexn - nexilin

Predicted to enable actin filament binding activity and cell-cell adhesion mediator activity. Predicted to be a structural constituent of muscle. Acts upstream of or within response to bacterium. Predicted to be located in Z disc; actin cytoskeleton; and focal adhesion. Predicted to be active in axon and plasma membrane. Is expressed in diaphragm; gut; head mesenchyme; heart; and vertebral axis musculature. Used to study dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]