Mypn - myopalladin

Predicted to enable SH3 domain binding activity; cell-cell adhesion mediator activity; and muscle alpha-actinin binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and sarcomere organization. Located in I band. Colocalizes with Z disc. Is expressed in diaphragm; eye; heart; tongue muscle; and vertebral axis musculature. Used to study nemaline myopathy 11 and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1KK and nemaline myopathy 11. Orthologous to human MYPN (myopalladin). [provided by Alliance of Genome Resources, Apr 2022]