Washc1 - WASH complex subunit 1

Enables gamma-tubulin binding activity. Involved in several processes, including meiotic nuclear division; negative regulation of phosphatidylinositol 3-kinase activity; and protein localization to cell surface. Acts upstream of or within several processes, including Arp2/3 complex-mediated actin nucleation; low-density lipoprotein particle clearance; and positive regulation of cholesterol import. Located in autophagosome; centrosome; and endosome. Part of BLOC-1 complex and WASH complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to several human genes including WASHC1 (WASH complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]