Iqsec2 - IQ motif and Sec7 domain ArfGEF 2

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of glutamatergic synaptic transmission and positive regulation of long-term synaptic depression. Predicted to be located in presynaptic active zone cytoplasmic component. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Apr 2022]