Enables glucose-6-phosphatase activity. Acts upstream of or within glucose-6-phosphate transport. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in severe congenital neutropenia 4. Orthologous to human G6PC3 (glucose-6-phosphatase catalytic subunit 3). [provided by Alliance of Genome Resources, Apr 2022]