Cacna1s - calcium voltage-gated channel subunit alpha1 S

Enables high voltage-gated calcium channel activity. Involved in calcium ion transport. Located in dendritic spine head and sarcolemma. Part of voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in hypokalemic periodic paralysis and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Apr 2022]