Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of establishment of endothelial barrier; and regulation of vascular associated smooth muscle contraction. Acts upstream of or within hair follicle development; protein palmitoylation; and sebaceous gland development. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; eye; inner cell mass; oocyte; and trunk somite. Orthologous to human ZDHHC21 (zinc finger DHHC-type palmitoyltransferase 21). [provided by Alliance of Genome Resources, Apr 2022]