Spire1 - spire type actin nucleation factor 1

Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Is integral component of mitochondrial outer membrane. Colocalizes with cleavage furrow. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Apr 2022]