Nsd2 - nuclear receptor binding SET domain protein 2

Predicted to enable chromatin binding activity; histone methyltransferase activity (H3-K36 specific); and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including cardiac septum morphogenesis; histone lysine methylation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]