Tirap - TIR domain containing adaptor protein

Predicted to enable several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of gene expression; and positive regulation of signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway; myeloid cell differentiation; and response to bacterium. Predicted to be located in endocytic vesicle and ruffle membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]