Tcf7l2 - transcription factor 7 like 2

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]