Dgat2 - diacylglycerol O-acyltransferase 2

Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including cellular response to oleic acid; diacylglycerol biosynthetic process; and lipid homeostasis. Acts upstream of or within triglyceride biosynthetic process. Located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Is integral component of endoplasmic reticulum membrane. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]