Dnaaf4 - dynein axonemal assembly factor 4

Predicted to enable estrogen receptor binding activity. Involved in cilium movement; inner dynein arm assembly; and outer dynein arm assembly. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and learning or memory. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and spleen. Used to study Robinow syndrome and primary ciliary dyskinesia 25. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). [provided by Alliance of Genome Resources, Apr 2022]