Abhd5 - abhydrolase domain containing 5

Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and carboxylic ester hydrolase activity. Involved in negative regulation of sequestering of triglyceride and positive regulation of triglyceride catabolic process. Acts upstream of or within positive regulation of lipoprotein lipase activity. Located in cytosol and lipid droplet. Is expressed in central nervous system; dorsal root ganglion; epidermis; and retina. Used to study neutral lipid storage disease. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]