Jam2 - junction adhesion molecule 2

Predicted to enable integrin binding activity. Involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Acts upstream of or within negative regulation of cell adhesion. Located in cell surface; somatodendritic compartment; and tight junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]