Cltc - clathrin, heavy polypeptide (Hc)

Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit and photoreceptor ribbon synapse. Part of membrane coat. Is active in presynaptic endocytic zone membrane. Is expressed in 8-cell stage embryo; brain; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Apr 2022]