Cisd2 - CDGSH iron sulfur domain 2

Predicted to enable 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Involved in autophagy of mitochondrion and multicellular organism aging. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Is expressed in central nervous system and retina. Used to study Wolfram syndrome 2. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2). [provided by Alliance of Genome Resources, Apr 2022]