Clec14a - C-type lectin domain family 14, member a

Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Involved in cell migration involved in sprouting angiogenesis. Acts upstream of or within with a positive effect on vascular endothelial growth factor receptor-3 signaling pathway. Acts upstream of or within with a negative effect on vascular endothelial growth factor receptor-2 signaling pathway. Acts upstream of or within lymphangiogenesis and sprouting angiogenesis. Located in collagen-containing extracellular matrix. Is expressed in bladder; choroid plexus; diencephalon roof plate; and embryo mesenchyme. Orthologous to human CLEC14A (C-type lectin domain containing 14A). [provided by Alliance of Genome Resources, Apr 2022]