Uba5 - ubiquitin-like modifier activating enzyme 5

Enables UFM1 activating enzyme activity. Involved in erythrocyte differentiation; megakaryocyte differentiation; and protein ufmylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Apr 2022]