Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Apr 2022]