Map3k20 - mitogen-activated protein kinase kinase kinase 20

Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in intracellular signal transduction; limb development; and protein phosphorylation. Acts upstream of or within cytoskeleton organization and embryonic digit morphogenesis. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Apr 2022]