Tctn1 - tectonic family member 1

Involved in cilium assembly and protein localization to ciliary transition zone. Acts upstream of or within in utero embryonic development; nervous system development; and regulation of smoothened signaling pathway. Located in ciliary transition zone; extracellular space; and membrane. Part of MKS complex. Is expressed in several structures, including gut epithelium; neural tube; node; notochord; and somite. Human ortholog(s) of this gene implicated in Joubert syndrome 13. Orthologous to human TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Apr 2022]