Asb2 - ankyrin repeat and SOCS box-containing 2

Contributes to ubiquitin protein ligase activity. Involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Acts upstream of or within cellular protein metabolic process; myoblast differentiation; and skeletal muscle cell differentiation. Located in Z disc. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart; and musculature. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]