Asb4 - ankyrin repeat and SOCS box-containing 4

Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in positive regulation of vasculogenesis and protein autoubiquitination. Part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and limb. Used to study pre-eclampsia. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4). [provided by Alliance of Genome Resources, Apr 2022]