Agap2 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Enables protein kinase activator activity and protein kinase binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Apr 2022]