Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]