Vps35 - VPS35 retromer complex component

Enables D1 dopamine receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neurotransmitter receptor transport, endosome to postsynaptic membrane; and positive regulation of cell communication. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and postsynaptic density. Part of retromer complex. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Parkinson's disease 17. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]