Ireb2 - iron responsive element binding protein 2

Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; and response to iron ion. Located in axon; cytosol; and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]