P2ry12 - purinergic receptor P2Y12

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Located in basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]