Bad - BCL2-associated agonist of cell death

Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of cell death; and response to steroid hormone. Located in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); brain disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]