Nphs1 - NPHS1 adhesion molecule, nephrin

Enables alpha-actinin binding activity; protein domain specific binding activity; and spectrin binding activity. Predicted to be involved in several processes, including myoblast fusion; regulation of excretion; and skeletal muscle tissue development. Predicted to act upstream of or within JNK cascade; cell adhesion; and positive regulation of actin filament polymerization. Located in several cellular components, including basement membrane; membrane raft; and slit diaphragm. Part of protein-containing complex. Biomarker of end stage renal disease; kidney failure; membranous glomerulonephritis; and nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin). [provided by Alliance of Genome Resources, Apr 2022]