Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and response to morphine. Located in endosome; membrane raft; and plasma membrane. Colocalizes with sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Apr 2022]