Mfn2 - mitofusin 2

Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including mitochondrion organization; negative regulation of organelle organization; and regulation of reactive oxygen species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Is intrinsic component of mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); fatty liver disease (multiple); obesity; prediabetes syndrome; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2022]