Herpud1 - homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Enables ubiquitin ligase-substrate adaptor activity. Involved in protein targeting to ER; regulation of ER-associated ubiquitin-dependent protein catabolic process; and regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within endoplasmic reticulum unfolded protein response; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is integral component of membrane. Is expressed in several structures, including clavicle; craniocervical region bone; early conceptus; and olfactory epithelium. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Apr 2022]