Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of secretion by cell; and regulation of signal transduction. Located in several cellular components, including dendrite; mitochondrial intermembrane space; and neuronal cell body. Biomarker of obesity and transient cerebral ischemia. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Apr 2022]