Rapgef1 - Rap guanine nucleotide exchange factor 1

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of neuron projection development; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]