Actn4 - actinin alpha 4

Enables protein N-terminus binding activity. Involved in regulation of apoptotic process and response to hypoxia. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]