Nlrp1b - NLR family, pyrin domain containing 1B

Predicted to enable several functions, including ATP binding activity; cysteine-type endopeptidase activator activity; and nucleic acid binding activity. Acts upstream of or within protein catabolic process and pyroptosis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of NLRP1 inflammasome complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]