Jam2 - junctional adhesion molecule 2

Predicted to enable integrin binding activity. Predicted to be involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Predicted to act upstream of or within negative regulation of cell adhesion. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and tight junction. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]