Hcn4 - hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Predicted to enable cation channel activity and identical protein binding activity. Involved in cellular response to aldosterone and response to cisplatin. Located in basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4). [provided by Alliance of Genome Resources, Apr 2022]