Dact1 - dishevelled-binding antagonist of beta-catenin 1

Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in embryonic hindgut morphogenesis and regulation of signal transduction. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Apr 2022]