Nr1h3 - nuclear receptor subfamily 1, group H, member 3

Enables retinoid X receptor binding activity and sequence-specific DNA binding activity. Involved in several processes, including bile acid signaling pathway; insulin receptor signaling pathway; and response to cholesterol. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and premature menopause. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]