Enables phosphoglycerate dehydrogenase activity. Predicted to be involved in serine family amino acid biosynthetic process. Predicted to act upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]