Pmaip1 - phorbol-12-myristate-13-acetate-induced protein 1

Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and response to X-ray. Located in mitochondrion. Is expressed in several structures, including brain; immune system; limb; liver; and reproductive system. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]