Tk2 - thymidine kinase 2, mitochondrial

Predicted to enable deoxycytidine kinase activity and thymidine kinase activity. Acts upstream of or within deoxyribonucleotide metabolic process; mitochondrial DNA metabolic process; and mitochondrial DNA replication. Located in mitochondrion. Used to study mitochondrial DNA depletion syndrome 2. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]