Tbx21 - T-box 21

Enables DNA binding activity. Involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Acts upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]