Kcne3 - potassium voltage-gated channel, Isk-related subfamily, gene 3

Predicted to enable potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in cellular chloride ion homeostasis; potassium ion transmembrane transport; and sodium ion transport. Is active in basolateral part of cell. Is expressed in several structures, including branchial arch; ear; forelimb bud; gut; and heart. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]