Brd4 - bromodomain containing 4

Enables several functions, including RNA polymerase II C-terminal domain binding activity; chromatin binding activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including histone acetylation; inner cell mass cell proliferation; and protein autophosphorylation. Located in chromatin and condensed nuclear chromosome. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2022]